大肠埃希菌所致尿路感染药敏试验分析

目的研究尿路感染中大肠埃希菌的耐药性变迁,为临床用药提供参考。方法对2004年和2005年检出的89份尿液标本中的大肠埃希菌,采用K-B法药敏试验,并进行超广谱β-内酰胺酶(ESBLs)检测。结果2004年和2005年大肠埃希菌的检出率分别为29.9%和32.3%,产酶率分别为39.5%和51.0%,呈增高趋势。大肠埃希菌对哌拉西林/他唑巴坦、亚胺培南、丁胺卡那霉素、头孢他啶、呋喃妥因和复方新诺明耐药率较低,分别为2.2%、3.3%、14.6%、23.6%、32.6%和38.2%,而其他常用抗生素的耐药率均大于50%,另外ESBLs(+)细菌的检出率有上升趋势,ES-BLs(+)细菌对头孢菌素的耐药率普遍高于ESBLs(-)细菌(P(0.01)。结论尿路感染中的大肠埃希菌检出率和产酶率不断升高,临床医生应当根据药敏试验来选择抗生素。

Analysis of susceptibility test of Escherichia Coli in urinary tract infection

Objective To research the drug tolerance variation of Escherichia Coli in urinary tract infection,and to provide reference to clinical medication.Methods Eighty-nine Escherichia Coli infected urinary samples which were collected from 2004 to 2005 were carried out K-B method susceptibility test and ESBLs test.Results The detection rates of Escherichia Coli in 2004 and 2005 were 29.9% and 32.3 % respectively,and the production rates of enzyme were 39.5% and 51.0% respectively.Both showed an upward tendency.Escherichia Coli have a low drug tolerance rate for piperacillin/Tazobactam(2.2%),imipenem(3.3%),butylamine(14.6%),ceftazidime(23.6%),nitrofurantoin(32.6%) and cotrimoxazole(38.2%).As for other commonly used antibiotics,the rate was all over 50%.Also,ESBLs( ) bacterium showed a upward detection rate and generally had a higher drug tolerance rate than ESBLs(-) bacterium(P<0.01).Conclusion With an increasing detection rate and enzyme-producing rate of Escherichia Coli in urinary tract infection,clinicians should choose antibiotics based on susceptibility test.