| 肝移植治疗乙型肝炎、肝硬化并发肝癌的分析 |
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| 引用本文： | 韩建立,赵浩亮,杨高潮,赵瑛,刘建生,郭建昇,王世明,马艳波,魏志刚,付西峰,鲍民生.肝移植治疗乙型肝炎、肝硬化并发肝癌的分析[J].肿瘤研究与临床,2010,22(1):329-331. |
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| 作者姓名： | 韩建立 赵浩亮 杨高潮 赵瑛 刘建生 郭建昇 王世明 马艳波 魏志刚 付西峰 鲍民生 |
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| 作者单位： | 山西医科大学第一医院普外科,太原,030001; |
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| 摘 要： | 目的 研究乙型肝炎、肝硬化并发肝癌行肝移植手术时机的选择及术后免疫抑制剂的应用.方法 对9例患者施行肝移植,其中4例为经典式原位肝移植,5例为背驮式原位肝移植,术后应用免疫抑制剂甲基泼尼松龙、他克莫司及吗替麦考酚酯(商品名:骁悉),同时采用抗乙型肝炎免疫球蛋白及拉米夫定预防乙肝病毒复发.结果 9例肝癌肝移植手术均获成功,2例术前情况差的患者术后死于多器官衰竭,1例死于急性排斥反应,余6例全部生存至今.结论 乙型肝炎、肝硬化并发肝癌最有效的治疗方法之一是肝移植,手术在肝癌转移前进行疗效较好,术后应用免疫抑制剂甲基泼尼松龙、他克莫司及吗替麦考酚酯可以有效控制免疫排斥的发生.
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| 关 键 词： | 肝移植 肝硬化 肝肿瘤 |
Treatment of hepatitis B, liver cirrhosis complicated by liver carcinoma: liver transplantation |
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| HAN Jian-li,ZHAO Hao-liang,YANG Gao-chao,ZHAO Ying,LIU Jian-sheng,GUO Jian-sheng,WANG Shi-ming,MA Yan-bo,WEI Zhi-gang,FU Xi-feng,BAO Ming-sheng.Treatment of hepatitis B, liver cirrhosis complicated by liver carcinoma: liver transplantation[J].Cancer Research and Clinic,2010,22(1):329-331. |
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| Authors: | HAN Jian-li ZHAO Hao-liang YANG Gao-chao ZHAO Ying LIU Jian-sheng GUO Jian-sheng WANG Shi-ming MA Yan-bo WEI Zhi-gang FU Xi-feng BAO Ming-sheng |
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| Abstract: | Objective To summarize the clinical experiences of liver transplantation.Methods Of the nine patients, four operation was standard orthotopic liver transplantation,the latter five were the piggyback liver transplantation.The immunosuppressive protocols included methylprednisolone FK506 and mycophenolatemofeti. Meanwhile intravenous antihepatitis B immunoglobulin and Lamivudine were used to prevent hepatitis B recurrence.Results All patients were cured.Conclusion Liver transplantation can be employed for liver disease both cirrhosis and carcinoma as a conventional surgery.It is an effective way for the treatment of no metastatic liver carcinoma.The immunosuppressive protocols included methylprednisolone FK506 and mycophenolatemofeti,it can prevent immune rejection. |
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| Keywords: | Liver transplantationLiver cirrhosisLiver neoplasms |
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