| 哮喘易感基因的研究进展 |
| |
| 引用本文： | 金蕊. 哮喘易感基因的研究进展[J]. 国际儿科学杂志, 2011, 38(1): 203-206. DOI: 10.3760/cma.j.issn.1673-4408.2011.03.001 |
| |
| 作者姓名： | 金蕊 |
| |
| 作者单位： | 南京医科大学第一附属医院儿科,210029; |
| |
| 基金项目： | 国家自然科学基金资助项目江苏省医学重点人才项目资助 |
| |
| 摘 要： | 支气管哮喘(哮喘)是一种多基因遗传病,由易感基因和环境因素共同作用而发病.通过候选基因法、定位克隆法和全基因组关联研究共确定了数百个哮喘易感基因,主要包括β2肾上腺素能受体基因、白细胞介素4受体基因、微丝蛋白基因、心房利钠素前体A基因、Ⅰ型肌醇多聚磷酸4磷酸酶基因、解整合素.金属蛋白酶33基因、双肽酶10基因、视蛋白3基因、血清类黏蛋白1样蛋白3基因、磷酸二酯酶4D基因、几丁质酶3类1基因等,其中多个基因在独立人群中得到验证.
|
| 关 键 词： | 哮喘 遗传 易感基因 |
Progress of the genetic research on asthma |
| |
| JIN Rui. Progress of the genetic research on asthma[J]. International Journal of Pediatrics, 2011, 38(1): 203-206. DOI: 10.3760/cma.j.issn.1673-4408.2011.03.001 |
| |
| Authors: | JIN Rui |
| |
| Abstract: | Bronchial asthma is a chronic inflammatory disorder of the airways,caused by multiple genetic and environmental factors.Thtee key methods including candidate gene study,the positional cloning and genomewide association studies.are used for asthma susceptibility gene identification.There are many candidate genes that haye been identified as asthma susceptibility gene, including ADRB2,IL4R,FLG,NPPA,INPP4A,ADAM33, DPP10,OPN3,0RMDL3,PDE4D,CHBLI etc.Replication of genetic associations and demonstration of a functional mechanism for the associated gene variants are needed to COnfirm an asthmasusceptibility gene, this will help us to understand the aetiology of asthma and explore new drugs to treat asthma. |
| |
| Keywords: | AsthmaGeneticsSusceptibility genes |
|
|
