| 肝纤维化血清学指标水平与肝癌的相关性研究 |
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| 引用本文： | 孙宇,姜美凤,张利营. 肝纤维化血清学指标水平与肝癌的相关性研究[J]. 中国医药, 2011, 6(1): 406-407. DOI: 10.3760/cma.j.issn.1673-4777.2011.04.010 |
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| 作者姓名： | 孙宇 姜美凤 张利营 |
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| 作者单位： | 解放军第三○五医院检验科,北京,100017;解放军青岛空军第二疗养院检验科; |
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| 摘 要： | Objective To investigate the significance of serum fibrosis markers in liver fibrosis in liver neoplasms. Methods Radioimmunoassay was used to measure the level of serum procollagen (PC) Ⅲ, collagen type Ⅳ(Ⅳ-C), laminin LN and hyaluronic acid(HA) in 120 patients with liver neoplasms and 100 healthy people.Results Before therapy, the level of Ⅳ-C in the hepatocellular carcinoma group showed significant difference compared with those in control group (P＜0. 01 ). The levels of PCⅢ and LN in the hepatocellular carcinoma group were higher than those in control group ( P ＜ 0.05 ). Before therapy the levels of HA in metastatic cancer of liver group and extrahepatic malignant tumor group were higher than those in control group ( P ＜ 0. 05 ). Before and after the therapy the levels of hepatocellular carcinoma group serum PC Ⅲ, Ⅳ-C, LN and HA were significantly higher than those in the metastatic cancer of liver group ( P ＜ 0. 05). Before and after the therapy the levels of hepatocellula carcinoma group serum PC Ⅲ, Ⅳ-C, LN and HA were significantly difference ( P ＜ 0.05 ). Conclusions The levels of serum PC Ⅲ, Ⅳ-C, LN and HA are significantly related with the hepatocellular carcinoma. These markers can reflect the fibrosis degree of chronic hepatocellular carcinoma and will be an indicator of prognosis.
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| 关 键 词： | 肝肿瘤 前胶原 胶原Ⅳ型 层粘连蛋白 Collagen type Ⅳ |
Relevance between the measurement of serum fibrosis markers and hepatic carcinoma |
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| SUN Yu,JIANG Mei-feng,ZHANG Li-ying. Relevance between the measurement of serum fibrosis markers and hepatic carcinoma[J]. China Medicine, 2011, 6(1): 406-407. DOI: 10.3760/cma.j.issn.1673-4777.2011.04.010 |
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| Authors: | SUN Yu JIANG Mei-feng ZHANG Li-ying |
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| Abstract: | |
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| Keywords: | Liver neoplasmsProcollagenLaminin |
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