益气活血治疗急性冠脉综合征临床回顾研究

目的探讨急性冠脉综合征(ACS)的中医证候学特点及中西医结合治疗ACS的可能机制。方法回顾性分析急诊科病历40例。结果ACS的主要证候是气虚血瘀;治疗方法突出了益气活血的主要治则。结论ACS病机特点属本虚标实。中药益气活和血药物通过抗脂质过氧化,清除自由基,增强机体抗氧化能力,维护血管内皮功能,下调MMP-2、MMP-9的基因表达,抑制纤维斑块内ECM降解,起到稳定纤维斑块作用。这些机制可能是益气活血中药在临床有效性的基本机制。

Clinical retrospective study of supplementing Qi and activating blood circulation on acute coronary syndrome

Objective It is to discuss the syndrome characteristic of acute coronary syndrome(ACS) and the possible therapy mechanism with integrated traditional Chinese and western medicine.Methods 40 patients were retrospective studied who were diagnosed ACS in Emergency Department.Results The predominant syndrome specialty of ACS was blood stasis due to Qi deficiency.The therapy expressed the treatment principle of supplying Qi and activating blood circulation.Conclusion The pathogenesis specialty of ACS is deficiency origin and excess in superficiality.The herb of supplying Qi and activating blood circulation can stabilize fiber spot with anti-lipid hydroperoxy,clearing free radicals to strength the body's ability of anti-oxidize,vindicating vascular endothelial function,descending gene expression of MMP-2,MMP-9 to restrain the solution of ECM in fiber spot,which may be the basic mechanism in clinical curative effect of the herb of supplying Qi and activating blood circulation.