长效硝苯地平与长效美托洛尔的动态降压作用比较

12例原发性高血压患者(男性5例,女性7例;年龄40±4a)自身交叉服用长效硝苯地平(下称Nif)20mg, qm×2wk;长效美托洛尔(下称Met)0.1g, qm×2wk。结果:踏车运动试验时服Njf者血压及心率明显升高;但服Met者能平稳地控制血压及心率。24h动态血压中平均动脉压在服上述2药后均显著下降(P<0.05),服Met者舒张压、心率下降较明显(P<0.05),且不良反应小,故Met优于Nif。

Comparison of ambulatory hypotensive effects with long-acting metoprolol and nifedipine

Twelve patients (M5, F7; age 40 ?4a) with primary hypertension underwent a crossover study with oral administration of sustained-release formulations of nifedipine tablet 20 mg, each morning at 8AM X 2 wk and metoprolol tablet 0.1g, each morning at 8 AM X 2 wk. The rises of blood pressure (BP) and heart rate (HR) during ergometer exercise test were less under metoprolol than under nifedipine. Both nifedipine and metoprolol lowered the 24-h BP during ambulatory monitoring (P< 0. 05), but metoprolol induced a more stable reduction of BP and HR in whole day. Metoprolol lowered diastolic pressure and HR (P<0. 05). There were lower incidences of adverse effects in metoprolol group than nifedipine group. It is suggested that metoprolol is superior to nifedipine.