新型药物载体-醇质体的特点及研究进展 |
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引用本文: | 林碧雯,王文娟,王洪权,周 勇,李恒进. 新型药物载体-醇质体的特点及研究进展[J]. 中国药物应用与监测, 2014, 0(2): 121-124 |
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作者姓名: | 林碧雯 王文娟 王洪权 周 勇 李恒进 |
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作者单位: | [1]解放军总医院皮肤科,北京100853; [2]军事医学科学院5所药学室,北京100071 |
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基金项目: | 解放军总医院苗圃基金(13KMM06) |
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摘 要: | 醇质体作为一种新型脂质体,具有包封率高、变形性好、皮肤刺激性小、透皮效果佳、皮肤滞留量大、可以进行细胞内传递药物等优点,使其在经皮给药过程中更加有效.本文根据国内外文献,对醇质体的特点、透皮吸收性及在抗感染药、激素透皮给药、关节炎用药及大分子药物透皮递送等方面的应用进行综述,结果表明醇质体具有良好的应用前景和开发价值.
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关 键 词: | 醇质体 脂质体 经皮给药 |
Characteristics and research progress of ethosomes-a new drug delivery carrier |
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Affiliation: | LIN Bi-wen1, WANG Wen-juan1, WANG Hong-quan2, ZHOU Yong1, LI Heng-jin1(1. Department of Dermatology, PLA GeneralHospital, Beijing 100853, China; 2. Department of Pharmacy, Academy of Military Medical Sciences, Beijing 100071, China) |
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Abstract: | As a new kind of liposome, ethosomes have some advantages, such as high encapsulation efficiency, good deformability, low skin irritation, good transdermal permeation, massive skin retention as well as increasing the drug concentration in theskin and providing effective intracellular transmission. Ethosomes have been found to be much more efficient in delivering drugto the skin than other drug delivery system (DDS), and have caught lots of research interest in the transdermal DDS. According tosome domestic and overseas literatures, the characteristics, transdermal absorption, transdermal delivery in terms of anti-infection,hormone, arthritis and macromolecular drugs of ethosomes were reviewed. The results indicated that the ethosomes have a goodapplication prospect and development value as drug carrier in transdermal DDS. |
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Keywords: | Ethosomes Liposomes Transdermal drug delivery |
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