| 颞下颌关节骨关节病发展过程中诱导型一氧化氮合酶在其软骨组织内的表达和意义 |
| |
| 引用本文： | 高占巍,王大章,刘宝林,马海欢. 颞下颌关节骨关节病发展过程中诱导型一氧化氮合酶在其软骨组织内的表达和意义[J]. 华西口腔医学杂志, 2007, 25(3): 216-218 |
| |
| 作者姓名： | 高占巍 王大章 刘宝林 马海欢 |
| |
| 作者单位： | 卫生部中日友好医院,整形外科,北京,100029;第四军医大学口腔医学院,颌面外科学教研室,陕西,西安,710032;四川大学华西口腔医学院,颌面外科学教研室,四川,成都,610041;第四军医大学口腔医学院,颌面外科学教研室,陕西,西安,710032;卫生部中日友好医院,整形外科,北京,100029 |
| |
| 摘 要： | 目的研究颞下颌关节骨关节病（TMJOA）发生发展过程中诱导型一氧化氮合酶（iNOS）在其软骨组织内的表达和作用。方法采用山羊建立TMJOA动物模型，在各组动物注射胶原酶后的2、4、12、24周时，分别切取其TMJ标本做EnVision二步法免疫组化检测。结果正常组TMJ软骨无iNOS表达，在实验组动物TMJOA发病过程中其软骨组织iNOS的表达有明显增加，且随着病变过程的发展与病变组织有一定的对应性。结论iNOS在TMJOA发生发展过程中起着重要的作用，抑制iNOS的生成有可能会阻断TMJOA的发生和发展。
|
| 关 键 词： | 颞下颌关节骨关节病 诱导型一氧化氮合酶 软骨 |
| 文章编号： | 1000-1182（2007）03-0216-03 |
| 收稿时间： | 2007-06-25 |
| 修稿时间： | 2006-12-052007-03-05 |
Expression of Inducible Nitric Oxide Synthase in Cartilage in Progression of Temporomandibular Joint Osteoarthritis |
| |
| GA Zhan-wei,WANG Da-zhang,LIU Bao-lin,MA Hai-huan. Expression of Inducible Nitric Oxide Synthase in Cartilage in Progression of Temporomandibular Joint Osteoarthritis[J]. West China journal of stomatology, 2007, 25(3): 216-218 |
| |
| Authors: | GA Zhan-wei WANG Da-zhang LIU Bao-lin MA Hai-huan |
| |
| Affiliation: | 1. Dept. of Plastic Surgery, China - Japan Friendship Hospital, Beijing 100029, China; 2. Dept. of Oral and Maxillofacial Surgery, The Fourth Military Medical University, Xi′an 710032, China; 3. Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China |
| |
| Abstract: | Objective To study the expression of inducible nitric oxide synthase(iNOS) in cartilage of temporo- mandibular joint osteoarthriti(TMJOA), and to evaluate the role of iNOS in the progression of TMJOA. Methods The goats were used and TMJOA was induced by injection of collagenase in upper joint space. The joints were obtained and were investigated by using immunohistochemistry at 2, 4, 12, 24 weeks after injection. Results Almost no expression of iNOS in normal cartilage of TMJ. In the diseased joints, strong or definite iNOS reactivity was expressed. Conclusion iNOS plays an important role in the progression of TMJOA. |
| |
| Keywords: | temporomandibular joint osteoarthfitis inducible nitric oxide synthase cartilage |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《华西口腔医学杂志》浏览原始摘要信息 |
|
点击此处可从《华西口腔医学杂志》下载全文 |
|
