| 牙龈卟啉单胞菌脂多糖对人牙周膜成纤维细胞胶原吞噬作用的影响 |
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| 引用本文： | 方厂云,苏征,陈蕾,樊明文,翦新春,陈智. 牙龈卟啉单胞菌脂多糖对人牙周膜成纤维细胞胶原吞噬作用的影响[J]. 华西口腔医学杂志, 2007, 25(4): 339-341 |
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| 作者姓名： | 方厂云 苏征 陈蕾 樊明文 翦新春 陈智 |
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| 作者单位： | 中南大学湘雅医院,口腔科,湖南,长沙,410008;武汉大学口腔医院,牙体牙髓科,湖北,武汉,430079 |
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| 摘 要： | 目的研究牙周病致病菌牙龈卟啉单胞菌脂多糖（LPS）对体外培养的人牙周膜成纤维细胞（hPDLF）胶原吞噬作用的影响。方法将不同质量浓度的LPS加入体外培养的hPDLF 48 h后，采用荧光定位术和流式细胞技术检测hPDLF胶原吞噬率的变化。结果LPS导致hPDLF胶原吞噬率显著增加（P<0.05）。结论牙龈卟啉单胞菌脂多糖具有促进hPDLF吞噬胶原的作用，可能是牙周组织破坏机制之一。
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| 关 键 词： | 牙龈卟啉单胞菌 脂多糖 牙周膜成纤维细胞 胶原 吞噬 |
| 文章编号： | 1000-1182（2007）04-0339-03 |
| 收稿时间： | 2007-08-25 |
| 修稿时间： | 2006-11-13 |
Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts |
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| FANG Chang-yun,SU Zheng,CHEN Lei,FAN Ming-wen,JIAN Xin-chun,CHEN Zhi. Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts[J]. West China journal of stomatology, 2007, 25(4): 339-341 |
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| Authors: | FANG Chang-yun SU Zheng CHEN Lei FAN Ming-wen JIAN Xin-chun CHEN Zhi |
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| Affiliation: | 1. Stomatological Department, Xiangya Hospital of Central South University, Changsha 410008, China; 2. Dept. of Operative Dentistry, Cariology and Endodontology, Stomatological College of Wuhan University, Wuhan 430079, China |
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| Abstract: | OBJECTIVE: To investigate the effects of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on collagen phagocytosis of human periodontal ligament fibroblasts (hPDLF). METHODS: Fluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro. RESULTS: The collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05). CONCLUSION: This study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis. |
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| Keywords: | Porphyromonas gingivalis lipopolysaccharide periodontal ligament fibroblasts collagen phagocytosis |
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