| p21~(WAF1/CIP1)和P53蛋白在子宫平滑肌肿瘤的表达和意义 |
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| 引用本文： | 孙立奇,石一复,周彩云. p21~(WAF1/CIP1)和P53蛋白在子宫平滑肌肿瘤的表达和意义[J]. 现代妇产科进展, 2003, 12(1): 31-33 |
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| 作者姓名： | 孙立奇 石一复 周彩云 |
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| 作者单位： | 1. 浙江省湖州市妇幼保健院,湖州,313000
2. 浙江大学医学院附属妇产科医院 |
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| 摘 要： | 目的 :探讨p2 1WAF1/CIP1和P5 3蛋白在子宫平滑肌肿瘤 (USMTs)的表达和意义。方法 :应用免疫组织化学法检测 2 0例普通型子宫平滑肌瘤 (UL) ,18例子宫平滑肌肉瘤 (LMS)及 70例交界性子宫平滑肌瘤 (BLM) :包括 4 0例富于细胞型子宫平滑肌瘤 (CL)、13例奇异型子宫平滑肌瘤 (BL)、4例核分裂活跃型子宫平滑肌瘤 (ML)、10例不典型子宫平滑肌瘤 (AL)及 3例恶性潜能未定型子宫平滑肌瘤 (STUMP)的p2 1WAF1/CIP1和P5 3蛋白的表达。结果 :LMS组p2 1WAF1/CIP1蛋白表达阳性率明显高于UL组 (P <0 .0 1)和BLM组 (P<0 .0 1) ;LMS组P5 3蛋白表达阳性率显著高于UL组 (P <0 .0 1)和BLM组 (P <0 .0 1)。结论 :LMS的发病机制涉及P5 3基因功能的丧失 ;p2 1WAF1/CIP1在USMT细胞的增殖和灭活中可能起到不同的作用
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| 关 键 词： | 子宫肿瘤 平滑肌瘤 蛋白质,p21 蛋白质,P53 |
| 文章编号： | 1004-7379(2003)01-0031-03 |
| 修稿时间： | 2001-05-30 |
The expression and significance of p21WAF1/CIP1 and P53 in human uterine smooth muscle tumors |
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| Sun Liqi ,Shi Yifu ,Zhou Caiyun ..Huzhou Maternity and Children Health Institute,Huzhou,. The expression and significance of p21WAF1/CIP1 and P53 in human uterine smooth muscle tumors[J]. Current Advances In Obstetrics and Gynecology, 2003, 12(1): 31-33 |
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| Authors: | Sun Liqi Shi Yifu Zhou Caiyun ..Huzhou Maternity Children Health Institute Huzhou |
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| Affiliation: | Sun Liqi 1,Shi Yifu 2,Zhou Caiyun 2.1.Huzhou Maternity and Children Health Institute,Huzhou,313000,2.The Affiliated Obstetrical and Gynecological Hospital of Medical College of Zhejiang University |
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| Abstract: | Objective:To investigate the expression and significance of p21 WAF1/CIP1and P53 protein in human uterine smooth muscle tumors (USTMs).Methods:Immunohistochemical technique was used to detect the p21 WAF1/CIP1and P53 protein expressions in:20 usual leiomyoma (UL),70 borderline leiomyoma (BLM):including 40 cellular leiomyoma (CL),13 bizarre leiomyoma (BL),4 mitotically active leiomyoma (ML),10 atypical leiomyoma (AL), 3 smooth muscle tumors of uncertain malignant potential (STUMP) and 18 leiomyosarcoma (LMS).Results:The positive rate of p21 WAF1/CIP1protein expression in LMS was clearly higher than that of UL (P<0.01)and BLM (P<0.01).The positive rate of P53 protein expression in LMS was clearly higher than that of UL (P<0.01)and BLM (P<0.01).Conclusion:A loss of P53 function is implicated in the pathogenesis of LMSs and p21 WAF1/CIP1may play different role in proliferation and inactivation of USMT cells. |
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| Keywords: | Uterine neoplasms Leiomyoma Protein p21 Protein P53 |
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