| p14ARF在宫颈癌中的表达及其与p53 表达相关性的研究 |
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| 引用本文： | 何培芝,刘少扬,江大琼.p14ARF在宫颈癌中的表达及其与p53 表达相关性的研究[J].肿瘤防治研究,2005,32(1):27-29. |
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| 作者姓名： | 何培芝 刘少扬 江大琼 |
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| 作者单位： | 430071 武汉大学附属中南医院妇瘤科 |
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| 摘 要： | 目的 探讨宫颈癌组织p14ARF蛋白的表达及其与p53 表达的相关性。方法 应用免疫组化方法检测p14ARF 、p53 基因在41 例宫颈癌及20 例正常宫颈组织中的表达。结果 p14ARF在正常宫颈组织中不表达,41 例宫颈癌中35 例表达阳性,占85. 4 %。病理分级为G1 、G2 级的宫颈癌的p14ARF阳性表达率为68. 4 % ,G3 级为100 % ,两者比较,有显著性差异( P < 0. 05) 。宫颈癌组织中p53 蛋白表达阳、阴性者中p14ARF蛋白表达阳性率分别为75. 0 %(12/ 16) 和92. 0 %(23/ 25) ,两者比较,无显著性差异,p14ARFF与p53 表达不相关。结论 p14ARF在宫颈癌中高表达有一定的诊断和估测预后价值,可能是宫颈癌新的肿瘤标志。
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| 关 键 词： | p14ARF p53 宫颈肿瘤 免疫组织化学 |
| 收稿时间： | 2004-3-1 |
| 修稿时间： | 2004-9-6 |
Expression of p14ARF and p53 Protein in Cervical Carcinomas |
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| HE Pei-zhi,L IU Shao-yang,J IANG Da-qiong.Expression of p14ARF and p53 Protein in Cervical Carcinomas[J].Cancer Research on Prevention and Treatment,2005,32(1):27-29. |
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| Authors: | HE Pei-zhi L IU Shao-yang J IANG Da-qiong |
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| Institution: | Department of Gy necologic Oncology , Zhongnan Hospital of Wuhan University |
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| Abstract: | Objective To study the expression of p14ARF protein in cervical carcinoma and it s relationship with the expression of p53 gene. Methods The expression of p14ARFand p53 protein was detected by immunohistochemist ry in 41 cervical carcinoma tissues and 20 normal cervical tissues. Results p14ARFwas expressed in 35 of 41 (85. 4 %) cases of cervical carcinomas. In cont rast ,normal cervical epithelium did not express p14ARF . Overexpression of p14ARF was related to the tumor grade. The expression of p14ARF had no association with p53. Conclusion The overexpression of p14ARF has value in diagnostic and prognosis in cervical neoplasm. These proteins maybe use as new markers of cervical neoplasm. |
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| Keywords: | p14ARF" target="_blank">ARF')" href="#">p14ARF p53 Cervix neoplasm Immunohistochemistry |
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