大肠癌高发区居民结肠癌危险因素研究

目的 研究我国结直肠癌最高发达地区浙江嘉善县结肠癌危险因素,为监测和预防结肠癌提供科学依据。方法 采用以全人群为基础的病例对照研究,用统一的调查表调查了109对结肠癌病例和对照（病例对照之比为1：7）,应用Logistic回归对结肠癌相关变量进行了单因素和多因素分析。结果 10年前猪肉月均消耗量高（OR＝1.723)、下消化系统疾病（OR＝4．163）和一级亲属结直肠癌史（OR＝3．421）是嘉善县结肠癌主要危险因素;10年前蔬菜月均消耗量高则为发生结肠癌的保护因素（OR＝0．422）。结论 嘉善县结肠癌与饮食因素有关。研究结果支持结肠癌发生的脂肪胆汁酸假说及纤维缺乏假说。精神压抑、遗传和下消化系统疾病也与结肠癌发病密切相关。

Colon cancer risk factors in Jiashan county, Zhejiang province, the highest incidence area in China

OBJECTIVE: To investigate the risk factors of colon cancer in the highest incidence area, Jiashan county, providing scientific basis for monitoring and prevention. METHODS: With a population-based case-control study, 109 colon cancer patients with 1:7 matched controls were interviewed with uniform questionnaires. Conditional logistic regression was used for univariate and multivariate analysis of colon cancer. RESULTS: Ten years before, high monthly pork consumption (OR = 1.608), high monthly animal oil consumption (OR = 1.391), psychological depression (OR = 9.887), negative emotion (OR = 1.723), lower digestive tract diseases (OR = 4.163), and history of colorectal cancer in the first degree relatives (OR = 3.421) were the main risk factors of colon cancer. At that time, high monthly vegetable consumption was a protective factor for colon cancer (OR = 0.422). CONCLUSION: Colon cancer in Jiashan county was related to dietary factors. The research results support the colon cancer etiological hypothesis of "fat-bile acid" and "deficiency of dietary fibres". Psychological depression, inheritance and lower digestive tract diseases were also correlated with colon cancer.