析因分析法研究槲皮素对芒果苷抗炎祛痰作用的影响

目的 研究芒果叶主要化学成分芒果苷和槲皮素在抗炎、祛痰作用上是否存在交互影响.方法采用二甲苯致小鼠 耳廓肿胀模型研究抗炎作用；采用小鼠气管排泌酚红模型研究祛痰作用；采用析因方差分析判断药物间是否存在交互影响.结果 与空白对照组比较,芒果苷组有抗炎和祛痰作用(P＜0.05),槲皮素组有抗炎作用(P＜0.01),但没有祛痰作用(P＞0.05).芒果苷+槲皮素组的抗炎作用强于芒果苷组(P＜0.01),两者之间没有交互作用(P＞0.05)；芒果苷+槲皮素组的祛痰作用明显高于芒果苷组(P＜0.01),且两者有交互影响(P＜0.05).结论 芒果苷有抗炎和祛痰作用,槲皮素有抗炎作用但没有祛痰作用；槲皮素在抗炎中占主要地位,芒果苷在祛痰中占主要地位；芒果苷与槲皮素合用,在抗炎作用中两者之间不存在药物交互影响；但两药在祛痰试验中有明显的协同效应,槲皮素能明显提高芒果苷的祛痰药效.

Interaction of Anti - inflammatory and Expectorant Effect between Mangiferin and Quercetin

Objective Mangiferin and quercetin are the main chemical compositions of mango leaves.This article is to investigate the interaction effects between mangiferin and quercetin when they are used for anti-inflammatory and expectorant purposes. Methods Xylene-induced mouse ear edema model was employed to study anti-inflammatory effect.Phenolsulfonphothalein excretion test is employed to study the expectorant effect.Factorial analysis of variance was employed to study interaction effects. Results The anti-inflammatory and expectorant effect of "Mangiferin+quercetin group" was respectively stronger than the "Mangiferin group"(p<0.01). Conclusion In expectorant test there exists interaction effect between mangiferin and quercetin,quercetin can significantly improve mangiferin’s expectorant effect.