| 眼镜蛇毒对大鼠丘脑网状核c-jun表达的影响 |
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| 引用本文： | 黄锐,刘敏,熊克仁. 眼镜蛇毒对大鼠丘脑网状核c-jun表达的影响[J]. 皖南医学院学报, 2013, 32(1): 13-15 |
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| 作者姓名： | 黄锐 刘敏 熊克仁 |
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| 作者单位： | 皖南医学院解剖学教研室 |
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| 基金项目： | 院中青年科研基金项目(WK201216) |
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| 摘 要： | 目的:观察眼镜蛇毒对大鼠丘脑网状核(thalamicreticular nucleus,TRN)c-jun表达的影响。方法:大鼠随机分为正常组、生理盐水组和眼镜蛇毒组,每组各6只。灌注固定、取脑包埋、石蜡切片。运用免疫组织化学染色法,观察并比较c-jun在各组大鼠TRN的分布情况。结果:眼睛蛇毒组大鼠TRN c-jun阳性细胞数及表达强度较正常组、生理盐水组均显著增高(P<0.01)。结论:眼镜蛇毒对大鼠TRN c-jun的表达有上调作用。
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| 关 键 词： | 眼镜蛇毒 丘脑网状核 c-jun 大鼠 |
Effect of naja naja atra venom on the expression of c-jun in thalamic reticular nucleus of rats |
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| HUANG Rui,LIU Min,XIONG Ke-ren. Effect of naja naja atra venom on the expression of c-jun in thalamic reticular nucleus of rats[J]. Acta Academiae Medicinae Wannan, 2013, 32(1): 13-15 |
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| Authors: | HUANG Rui LIU Min XIONG Ke-ren |
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| Affiliation: | Department of Anatomy,Wannan Medical College,Wuhu 241002,China |
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| Abstract: | Objective:To observe the effects of naja naja atra(N.atra,Chinese cobra) venom on the expression of c-jun in the thalamic reticular nucleus(TRN) of rats.Methods:Rats were randomly divided into groups of normal control,administration of saline or N.atra venom(n=6 for each group).After preparation of the animal models with intravital perfusion fixation,the brain tissues were taken out and embedded in paraffin for section.Immunohistochemistry technique was used to observe the expression of c-jun in the TRN from the rats in each group.Results:The c-jun positive cells in the TRN of rats intervened with N.atra venom were more numerous and more intensively expressed as compared with those from the controls and saline group(P<0.01).Conclusion:N.atra venom appears to facilitate up-regulation of c-jun expression in the TRN of rats. |
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| Keywords: | cobra venom thalamic reticular nucleus c-jun rat |
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