| MSX1基因多态性与山西地区非综合征性唇腭裂的相关性研究 |
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| 引用本文： | 南欣荣,谢耕耘,王杨红,王江波.MSX1基因多态性与山西地区非综合征性唇腭裂的相关性研究[J].实用口腔医学杂志,2013,29(1):105-108. |
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| 作者姓名： | 南欣荣 谢耕耘 王杨红 王江波 |
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| 作者单位： | 山西医科大学第一医院口腔科;山西省大同市第五人民医院;山西中医学院附属医院;长治医学院 |
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| 基金项目： | 太原市科技计划项目(编号:085191) |
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| 摘 要： | 目的:研究MSX1基因外显子区rs13127820(M146L)、rs62636562(A274V)位点多态性与非综合征性唇腭裂(non-syn-dromic cleft lip with or without cleft palate,NSCL/P)的关系。方法:通过聚合酶链反应-限制性片段长度多态性方法,检测243例非综合征性唇腭裂(NSCL/P)患者和292例正常对照者全血标本中MSX1基因rs13127820(M146L)、rs62636562(A274V)位点的多态性。结果:MSX1基因位点rs13127820(M146L)、rs62636562(A274V)基因型频率分布符合Hardy-Weinberg平衡;MSX1基因位点rs13127820(M146L)、rs62636562(A274V)等位基因频率分布在NSCL/P组与对照组之间差异有统计学意义(P<0.05)。结论:结果显示MSX1基因位点多态性与NSCL/P的发生有关。
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| 关 键 词： | MSX1 多态性 非综合征性唇腭裂 |
Association between muscle segment homeobox 1 gene polymorphism and non-syndromic cleft lip with or without palate in the chinese population of Shanxi province |
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| NAN Xinrong,XIE Gengyun,WANG Yanghong,WANG Jiangbo.Association between muscle segment homeobox 1 gene polymorphism and non-syndromic cleft lip with or without palate in the chinese population of Shanxi province[J].Journal of Practical Stomatology,2013,29(1):105-108. |
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| Authors: | NAN Xinrong XIE Gengyun WANG Yanghong WANG Jiangbo |
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| Institution: | 1.030001 Taiyuan,Department of Stomatology,Shanxi Medical University First Hospital,China;2.The Fifth People’s Hospital of Datong,Shanxi;3.Affiliated Hospital of Shanxi University of Traditional Chinese Medicine;4.Department of Stomatology,Changzhi Medical College |
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