| 自然流产患者绒毛滋养层细胞PCNA和caspase-3的表达 |
| |
| 引用本文： | 高海玲,管英俊,申志新,姜俊怡,步同亮,陈燕春.自然流产患者绒毛滋养层细胞PCNA和caspase-3的表达[J].解剖科学进展,2006,12(3):234-235,i0008. |
| |
| 作者姓名： | 高海玲 管英俊 申志新 姜俊怡 步同亮 陈燕春 |
| |
| 作者单位： | 潍坊医学院组胚教研室,山东潍坊,261042;潍坊医学院组胚教研室,山东潍坊,261042;潍坊医学院组胚教研室,山东潍坊,261042;潍坊医学院组胚教研室,山东潍坊,261042;潍坊医学院组胚教研室,山东潍坊,261042;潍坊医学院组胚教研室,山东潍坊,261042 |
| |
| 摘 要： | 目的从细胞增殖与细胞凋亡的角度探讨自然流产的发生机制。方法取正常早孕流产和自然流产病例各20例的绒毛组织,光镜观察绒毛形态学变化;免疫组织化学SP法检测增殖细胞核抗原(PCNA)及凋亡蛋白酶caspase-3在滋养层细胞中的表达。结果自然流产绒毛组织均出现不同程度的退行性改变,细胞滋养层的增殖指数较对照组降低,而细胞滋养层、合体滋养层的凋亡指数却明显升高。结论凋亡蛋白酶caspase-3可能参与自然流产的发生机制。
|
| 关 键 词： | 自然流产 滋养层 增殖细胞核抗原 caspase-3 |
| 文章编号： | 1006-2947（2006）03-0234-02 |
| 收稿时间： | 2006-02-17 |
| 修稿时间： | 2006年2月17日 |
Expression of PCNA and Caspase-3 in Trophoblasts in Patients with Spontaneous Abortion |
| |
| GAO Hai-ling,GUAN Ying-jun,SHEN Zhi-xin,JIANG Jun-yi,BU Tong-liang,CHEN Yan-chun.Expression of PCNA and Caspase-3 in Trophoblasts in Patients with Spontaneous Abortion[J].Progress of Anatomical Sciences,2006,12(3):234-235,i0008. |
| |
| Authors: | GAO Hai-ling GUAN Ying-jun SHEN Zhi-xin JIANG Jun-yi BU Tong-liang CHEN Yan-chun |
| |
| Abstract: | Objective To investigate the expression of proliferating cell nuclear antigen(PCNA) and caspase-3 in chorionic villi to provide the theoretical basis for the mechanism of spontaneous abortion in early pregnancy.Methods Samples of early pregnant chorionic villi were obtained from surgical aspiration and spontaneous abortion.Histological changes were observed with light microscopy.The expression of PCNA and apoptosis protease(caspase-3) was detected with immunohistochemical staining.Results The extensive pathological changes in cell morphology were observed in chorionic villi of spontaneous abortion,and the proliferation indexes of cytotrophoblasts and syncytiotrophoblasts were decreased compared with the control group,vice versa,the apoptosis indexes increased compared with courtrol.Conclusion The overexpression of caspase-3 may be involved in the mechanism of spontaneous abortion. |
| |
| Keywords: | spontaneous abortion trophoblast proliferating cell nuclear antigen caspase-3 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
