| 氟西汀对抑郁模型大鼠海马区胶质细胞源性神经营养因子mRNA表达的影响 |
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| 引用本文： | 张晓斌,张志珺,谢春明,隋玉秀,孙奕,奚广军.氟西汀对抑郁模型大鼠海马区胶质细胞源性神经营养因子mRNA表达的影响[J].东南大学学报(医学版),2009,28(3):228-232. |
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| 作者姓名： | 张晓斌 张志珺 谢春明 隋玉秀 孙奕 奚广军 |
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| 作者单位： | 东南大学附属中大医院,神经内科,江苏,南京,210009 |
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| 摘 要： | 目的: 探讨抗抑郁药氟西汀对抑郁模型大鼠海马区胶质细胞源性神经营养因子(GDNF)mRNA表达的影响.方法: 将雄性SD大鼠随机分为对照组、对照加药组、抑郁组及抑郁加药组4组.以慢性轻度不可预见性的应激结合孤养法建立抑郁动物模型,对照加药组、抑郁加药组予氟西汀5 mg*kg-1*d-1腹腔注射,对照组、抑郁组予蒸馏水腹腔注射.采用旷野试验和蔗糖水消耗实验观察大鼠行为改变,荧光实时定量PCR检测各组大鼠海马区的GDNF mRNA表达水平.结果: 应激21 d后,抑郁组和抑郁加药组海马区的GDNF mRNA表达水平显著高于对照组和对照加药组(P＜0.05和P＜0.01).结论: 应激可能通过机体的反馈调节作用引起大鼠海马区GDNF mRNA的表达增高,氟西汀对大鼠海马区GDNF mRNA的表达无明显影响.
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| 关 键 词： | 星型胶质细胞 胶质细胞源性神经营养因子 氟西汀 抑郁症 大鼠 |
Effect of fluoxetine on the mRNA expression of glia cell line-derived neurotrophic factor in the rat hippocampus of depression model |
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| ZHANG Xiao-bin,ZHANG Zhi-jun,XIE Chun-ming,SUI Yu-xiu,SUN Yi,XI Guang-jun.Effect of fluoxetine on the mRNA expression of glia cell line-derived neurotrophic factor in the rat hippocampus of depression model[J].Journal of Southeast Univ: Medical Sci Ed,2009,28(3):228-232. |
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| Authors: | ZHANG Xiao-bin ZHANG Zhi-jun XIE Chun-ming SUI Yu-xiu SUN Yi XI Guang-jun |
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| Institution: | Department of Neurology;Zhongda Hospital;Southeast University;Nanjing 210009;China |
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| Abstract: | Objective To explore the effect of antidepressant drug(fluoxetine) on the mRNA expression of glia cell line-derived neurotrophic factor(GDNF) in the rat hippocampus of depression model.Methods Male Sprague-Dawley rats were divided into control group,control+fluoxetine group,depression model group and depression model+fluoxetine group.The depression model of rat was established by stimulation of separation and chronic mild unpredicted stress.The behavior was measured by open-field and sucrose water consumpti... |
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| Keywords: | astrocyte glial cell line-derived neurotrophic factor fluoxetine depression disorder rats |
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