自拟疏风通窍汤在鼻内镜术后鼻腔恢复中的应用

目的:观察自拟疏风通窍汤在内镜鼻窦手术(endoscopic sinus surgery,ESS)后术腔黏膜恢复过程中的作用。方法:120例(235侧)均为施行ESS的慢性鼻窦炎鼻息肉患者,随机分为两组,治疗组60例(118侧)鼻内镜术后第三天,撤出鼻腔之止血海绵,次日应用疏风通窍汤内服兼鼻腔浸浴;对照组60例(117侧)采用传统方法冲洗鼻腔。两组分别于鼻内镜术后2、8、14周钳取上颌窦口附近的黏膜组织进行观察。比较两组患者在黏膜转归中各阶段的差异。结果:治疗组比对照组在术腔清洁阶段、黏膜转归竞争阶段和上皮化完成阶段,与对照组比较,侧次均有显著性差异(P<0.05);光镜下治疗组术腔黏膜鳞状上皮化生,纤维组织增生等指标与对照组比较,侧次均有显著性差异(P<0.05)。结论:疏风通窍汤内服加局部鼻腔浸浴可促进鼻内镜术后术腔黏膜的恢复,安全易于操作。

Effect on the Recovery Process of Post-operation of Nasal Endoscope Influenced by Chinese Soup Preparation ofShufengTongqiao Decoction

Objective： To assess the action of Chinese soup preparation of ShufengTongqiao Decoction on the recovery of nasal sinus mucosa after endoscopic sinus surgery （ESS）. Methods： One hundred and twenty patients （235 sinus） with chronic nasosinusitis, who had undergone ESS, were divided into two groups. The 60 patients （ 118 sinuses） in the experiment group were treated with daily nasal flushing and taking orally with Chinese soup preparation of ShufengTongqiao Decoction while the 60 patients （117sinuses） in the control group were treated by conventional means. Tissues of nasal mucosa were taken out from patients maxillary sinus ostium at different time points, I. e. 2 weeks, 8 weeks, 10 weeks after ESS were observed. Compared with the recovery process of nasal sinus mueosa of the two groups. Results： Significant differences were shown between the two groups at all the time points in occurrence （patient/sinus） （P〈0. 05）. Light microscopic examination showed significant differ- ences between the two groups in occurrence （patient/sinus） of squamous epithelial metaplasia and fiber tissues proliferation （P gO. 05）. Conclusion： Using Chinese soup preparation of ShufengTongqiao Decoction for postoperative nasal flushing and taking orally after ESS is a manageable approach with effects in promoting nasal mucosa recovery.