Dose-response curves of homovanillic acid in pre-frontal cortex and caudate following antipsychotic drugs: relation to clinical potencies |
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Authors: | W-H Chang T-Y Chen H-S Wu W-H Hu E-K Yeh |
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Institution: | (1) Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 54, Alley 200, Lane 151, Section 5, Shin-Yi Road, 10510 Taipei, Taiwan, Republic of China |
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Abstract: | Dose-response curves for the elevation of homovanillic acid (HVA) levels, determined by high performance liquid chromatography using electrochemical detection, in the pre-frontal cortex and caudate of rats after acute treatment with 12 antipsychotic drugs are presented. The order of potency in both brain regions was: haloperidol fluphenazine > loxapine > trifluoperazine > thiothixene > molindone > clopenthixol > chlorpromazine > metoclopramide > thioridazine > clozapine > sulpiride. This ranking is roughly correlated with that based on clinical potencies. The relative elevation of the content of HVA was weaker in the pre-frontal cortex than in the caudate for all drugs tested, except clozapine at a high dose. |
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Keywords: | Dose-response curve Homovanillic acid Prefrontal cortex Caudate Antipsychotic drugs |
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