复方甲硝唑缓释药膜的制备与质量控制

目的；研制一种局部吸收较好的复方甲硝唑缓释药膜。方法：４０例典型牙周病人分为２组，一组ｐｏ甲硝唑０．２ｇ，另一组在牙周袋内插入缓释药膜，采用紫外分光光度法，测定龈沟中药物浓度。结果；复方甲硝唑缓释药膜的用量是片剂的１／２００，而龈沟中的药物浓度是片剂的６０倍。在促渗透剂的联合作用下，吸收明显增强。结论；复方甲硝唑缓释药膜治疗牙周炎，局部用药优于全身用药。

The preparation and quality control of the gingival cnevicalar fluid of compound metronidazole

OBJECTIVE:To develop the gingival cnevicular fluid of compound metronidazole,which is well locally absorbed.METHOD:Forty patients suffering from periodantitis mene were divided into two groups.One group took 0.2g of metronidazole,and the other mene inserted into their perodontal pockets with sustained-release film,and then the drug consistency(tensity) in gingival sulci could be determined with ultraviolet spectrophotometry.RESULTS:The dose of sustained release film of compound metronidazole is as much as that of 1/200 of tablets,while the drug consistency(tensity) in gingival sulci is 60times as much as that of tablets.In combination with penetrants,its absorption effect would be greatly improved.CONCLUSION:In treating periodantitis with gingival cnericutar fluid of compound metronidzole,local pharmacy is superior to that of whole-body.