| 活性氧、锰型超氧化物歧化酶对胃肠道肿瘤凋亡的影响 |
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| 引用本文： | 陈坚,林庚金,刘珊林. 活性氧、锰型超氧化物歧化酶对胃肠道肿瘤凋亡的影响[J]. 国际消化病杂志, 2006, 26(3): 186-188 |
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| 作者姓名： | 陈坚 林庚金 刘珊林 |
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| 作者单位： | 复旦大学附属华山医院消化内科,200040;复旦大学附属华山医院消化内科,200040;复旦大学附属华山医院消化内科,200040 |
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| 摘 要： | 活性氧(ROS)是近年来发现的调控肿瘤凋亡的重要信号分子之一,锰型超氧化物歧化酶(MnSOD) 是真核细胞内重要的酶性自由基清除剂,胃肠道肿瘤中存在MnSOD的高表达。此文综述了活性氧及MnSOD 对肿瘤凋亡的影响及信号转导机制,并介绍了以超氧化物歧化酶(SOD)作为新靶点进行肿瘤基因治疗的最新进展。
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| 关 键 词： | 活性氧 超氧化物歧化酶 凋亡 |
| 收稿时间： | 2005-04-13 |
| 修稿时间： | 2005-04-13 |
The influence of ROS and MnSOD on apoptosis of alimentary tract tumors |
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| CHEN Jian,LIN Geng-jin,LIU Shan-lin. The influence of ROS and MnSOD on apoptosis of alimentary tract tumors[J]. International Journal of Digestive Disease, 2006, 26(3): 186-188 |
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| Authors: | CHEN Jian LIN Geng-jin LIU Shan-lin |
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| Affiliation: | Gastroenterology Department, Huashan Hospital, Fudan University, Shanghai(200040;200032 |
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| Abstract: | Reactive oxygen species(ROS) is a new kind of signalling molecule in modulating tumor apoptosis. Manganese superoxide dismutase( MnSOD) is the major enzymatic ROS scavanger in eukaryocytes. MnSOD gene overexpression has been detected in alimentary tract malignancies. Here we review the influence of ROS and MnSOD on apoptotic signal transduction and the update of gene therapy targeted on MnSOD in digestive malignancies. |
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| Keywords: | Reactive oxygen species Manganese superoxide dismutase Apoptosis |
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