| 化痰活血法改善2型糖尿病模型大鼠胰岛素抵抗的作用机制研究 |
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| 引用本文： | 冯建华,姜国胜,徐云生,郭宝荣,唐天华,温培娥,董保华.化痰活血法改善2型糖尿病模型大鼠胰岛素抵抗的作用机制研究[J].中华中医药杂志,2009(8). |
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| 作者姓名： | 冯建华 姜国胜 徐云生 郭宝荣 唐天华 温培娥 董保华 |
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| 作者单位： | 山东中医药大学第二附属医院;山东省医学科学院基础研究所;山东中医药大学附属医院;山东中医药大学; |
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| 基金项目： | 国家自然科学基金项目(No.30371788) |
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| 摘 要： | 目的:研究化痰活血法对2型糖尿病胰岛素抵抗大鼠的影响与作用机制。方法:将健康SD大鼠,随机分为正常对照空白组和造模组,采用刘氏法建立2型糖尿病胰岛素抵抗大鼠模型;模型鼠又随机分成3组,即胰苏灵组、罗格列酮组、模型组,分别于给药后测定血糖、血脂、胰岛素、胰岛素受体数目与结合力,4周后禁食处死大鼠,留取血清并剪取肌肉、肝、脂肪等组织以检测GK、PEPCK以及脂肪组织TNF-αmRNA表达、肌肉组织GLUT-4mRNA表达、肝细胞GK的mRNA表达。结果:胰苏灵在改善胰岛素敏感指数,降糖、降脂、降低FFA等指标方面与罗格列酮未见明显差异(P>0.05),且胰苏灵可减轻大鼠体质量,研究发现T2DM大鼠模型肝GK活性明显低于空白组(P<0.05),脂肪组织TNF-αmRNA的表达水平明显高于对照组(P<0.05),PEPCK的蛋白定量及GLUT4的表达水平明显低于空白组(P<0.05),提示T2DM大鼠IR与与肝葡萄糖激酶活性降低、脂肪源性TNF-αmRNA高表达、PEPCK活性减低及GLUT4的表达降低密切相关。胰苏灵可以提高T2DM大鼠模型肝葡萄糖激酶活性、脂肪源性TNF-αmRNA的表达水平、增加PEPCK的活性...
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| 关 键 词： | 化痰活血法 2型糖尿病胰岛素抵抗 大鼠模型 实验研究 |
Study on mechanism of action of promoting blood circulation and dispersing phlegm method in improving insulin resistance of type 2 diabetes rats |
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| FENG Jian-hua,JIANG Guo-sheng,XU Yun-sheng,GUO Bao-rong,TANG Tian-hua,WEN Pei-e,DONG Bao-hua.Study on mechanism of action of promoting blood circulation and dispersing phlegm method in improving insulin resistance of type 2 diabetes rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(8). |
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| Authors: | FENG Jian-hua JIANG Guo-sheng XU Yun-sheng GUO Bao-rong TANG Tian-hua WEN Pei-e DONG Bao-hua |
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| Institution: | FENG Jian-hua1,JIANG Guo-sheng2,XU Yun-sheng3,GUO Bao-rong3,TANG Tian-hua2,WEN Pei-e2,DONG Bao-hua4(1The Second Affi liated Hospital of Sh,ong University of TCM,Jinan 250001,China,2Institute of Basic Medicine,SAMS,3The Affi liated Hospital of Sh,ong University of TCM,Jinan 250011,4Sh,ong University of TCM,Jinan 250014,China) |
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| Abstract: | Objective:To study the effects and mechanism of promoting blood circulation and dispersing phlegm in improving insulin resistance of type 2 diabetes rates.Methods:The healthy SD rats were randomly divided into two groups:control group and model group with type 2 diabetes.The model group was randomly divided into three groups:Yisuling group,rosiglitazome group and model group.Blood sugar,blood lipid,insulin,the number and combining force of insulin-receptor were detected after being treated with the drugs.Af... |
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| Keywords: | Promoting blood circulation and dispersing phlegm Insulin resistance of type 2diabetes Rats model Experimental study |
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