|
|||||
|
|
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis,releasing free PD-L1 on antigen-presenting cells |
|
| Authors: | Murat Tekguc James Badger Wing Motonao Osaki Jia Long Shimon Sakaguchi |
| Affiliation: | aLaboratory of Experimental Immunology, World Premier International (WPI) Immunology Frontier Research Center (IFReC), Osaka University, Suita 565-0871, Japan;bLaboratory of Human Immunology (Single Cell Immunology), WPI IFReC, Osaka University, Suita 565-0871, Japan;cDepartment of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan |
| Abstract: | |
| Keywords: | CTLA-4 trogocytosis regulatory T cells CD80/CD86 PD-L1 |