Left ventricular systolic and diastolic function and carotid intima-media thickness in pediatric dialysis patients |
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Authors: | Civilibal Mahmut Oflaz Huseyin Caliskan Salim Candan Cengiz Canpolat Nur Pehlivan Gulseren Sever Lale Kasapcopur Ozgur Arisoy Nil |
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Institution: | (1) Department of Pediatric Nephrology, Istanbul University Cerrahpasa Medical Faculty, Cerrahpasa, 34303 Istanbul, Turkey;(2) Department of Cardiology, Istanbul Medical Faculty, Istanbul, Turkey;(3) Department of Pediatric Nephrology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey |
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Abstract: | Background Cardiovascular complications are common in patients with end-stage renal disease (ESRD). We aimed to investigate left ventricular
(LV) function and carotid intima-media thickness (cIMT) in children and adolescents with ESRD.
Methods This study included 38 ESRD patients (15 hemodialysis and 23 peritoneal dialysis) and 17 age- and sex-matched healthy subjects.
Results The ESRD patients had significantly lower mean mitral E/A ratio, and higher left ventricular mass index (LVMI) and cIMT than
the control group. Compared with PD patients, HD patients had worse LV diastolic function. In stepwise linear regression analysis,
LVMI (P = 0.043) and hemoglobin (P = 0.015) turned out to be independent variables for predicting diastolic dysfunction (reduced E/A ratio), and the only significant
predictor of cIMT was indexed diastolic blood pressure (DBP) (P = 0.035).
Conclusion Cardiovascular structure and function abnormalities are also common in pediatric dialysis patients, as in adults. Furthermore
our data indicated that hemodialysis was disadvantageous for preserving LV diastolic function as compared with peritoneal
dialysis. |
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Keywords: | Carotid intima-media thickness Children Hemodialysis Left ventricular function Peritoneal dialysis |
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