γ-干扰素与结核病关系研究进展

γ-干扰素（Interferon-gamma,IFN-γ）是一种具有抗病毒、抗肿瘤和免疫调节作用的细胞因子,它与结核的发生、发展、转归、诊断及治疗都有着密切的关系。近年来IFN-γ在结核免疫发病中的作用受到重视,它是控制结核分枝杆菌感染的关键性Th1型细胞因子,基于其在结核病免疫中的特殊作用,IFN-γ目前已被用于结核病的诊断及免疫治疗等方面。现对IFN-γ在抗结核免疫中的作用,IFN-γ基因与结核易感性,利用IFN-γ诊断结核病的体外IFN-γ释放试验及IFN-γ对结核病的辅助治疗作用的研究进展做一综述,以期为结核病的预防、诊断和治疗提供参考。

Relationship between interferon-gamma and tuberculosis

Interferon-gamma （IFN-γ） is a kind of cytokine with the effects of anti -vires, anti-tumor and immunoregula- tion, and it has a close relationship with the occ- urrence, development, outcome, diagnosis and treatment of tuberculosis. In re- cent years, the role of IFN-γ in the immune incidence of tuberculosis gains attention. It is the key Thl-type cytokine which can control the infection of Mycobacterium tuber- culosis. Based on its special role in anti- tuberculosis immunity, IFN-γ has been used for the diagnosis and immunotherapy of tuberculosis. The following overview is focused on the research progress about the role of IFN-γ in the anti-TB immunity, IFN-γ gene and tuberculosis susceptibility, in vitro interferon gamma release assay for diagnosis of tuberculosis, and the adjuvant effect to tuberculosis of IFN-γ in order to provide a reference for the pre- vention, diagnosis and treatment of tuberculosis.