血管内皮抑素对小鼠肺癌影响的研究

目的观察血管内皮抑素（Endostatin）对小鼠体内Lewis肺癌生长、血管生成及转移的影响。方法将荷Lew is肺癌的C57鼠进行不同剂量组的内皮抑素血管内皮抑素和顺铂干预,观察肿瘤生长、移植瘤及转移瘤体内的微血管密度（MVD）的表达及转移发生率,采用SPSS19.0进行统计学分析。结果血管内皮抑素对鼠Lewis肺癌的生长有明显的抑制作用,并能显著下调移植瘤及转移瘤内微血管密度,减少肿瘤肺转移率,其作用程度与内皮抑素剂量呈现明显正相关,且血管内皮抑素中未见获得性耐药现象发生。结论血管内皮抑素可以通过下调肿瘤组织中的MVD,抑制肿瘤生长及减少转移的发生,不会诱发肿瘤对化疗药物的耐药现象发生,值得在抗癌治疗中使用。

Study of anti-angiogenestic and anti-metastatic effect of Endostatin on Lewis lung carcinoma xenograft in mice

Objective To investigate the anti-tumor, anti-angiogenestic and anti-metastatic effects of endostatin on lewis lung carcinoma xenograft in mice. Methods Different doses of Endostatin and Cisplatin were given to C57 mice burdened Lewis lung carcinoma xenograft, then tumor growth, MVD both in planted xenogrft tumor and metastatic tumor in lungs and uletastases rate were observed and analyzed statistically.Results Endostatin inhibited tumor growth down-regulated MVD both in planted xenogrft tumor and metastatic tumor in lungs and metastases rate, dose-dependent effect was observed in some degree. Conclusion Endostatin could inhibite the growth and metastases of Lewis lung carcinoma through down-regulating MVD both in planted xenogrft tumor and metastatic tumor in lungs, Worthy to use in the treatment of cancer.