| The Role of Serotonin 2C Receptor in Pulmonary Arterial Smooth Muscle Cells Proliferation and Contraction in Rats |
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| 引用本文： | ZHANG Bo LI Zhi-chao LIU Yi LUO Ying NIU Wen. The Role of Serotonin 2C Receptor in Pulmonary Arterial Smooth Muscle Cells Proliferation and Contraction in Rats[J]. 美中医学, 2007, 4(5): 18-21,33 |
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| 作者姓名： | ZHANG Bo LI Zhi-chao LIU Yi LUO Ying NIU Wen |
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| 作者单位： | Department of Pathophysiology, the Fourth Military Medical University, Xi＇an 710032 |
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| 摘 要： | Objective To examine the role of 5-HTEc receptor in pulmonary arterial smooth muscle cells （PASMCs） proliferation and contraction induced by 5-HT. Methods Small interfering RNA （siRNA） was used to knock down the expression of 5-HTEcR. We used MTT assay and cell cycle analysis to demonstrate the proliferation of PASMCs. The length of PASMCs was measured to show the cells contractile function. Results Administrated of 5-HTEcR-specific siRNA, 5-HTEc receptor expression in PASMCs was significantly suppressed. MTT assay and cell cycle analysis showed that 5-HT-induced cell growth in PASMCs was attenuated. Contraction of PASMCs induced by 5-HT was also obviously reduced. Conclusion 5-HTEc receptor mediates the proliferation and contraction of PASMCs induced by 5-HT.
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| 关 键 词： | 血液 复合胺 受体 肺动脉平滑肌细胞 增殖 收缩 鼠 |
The Role of Serotonin 2C Receptor in Pulmonary Arterial Smooth Muscle Cells Proliferation and Contraction in Rats |
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| Abstract: | |
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| Keywords: | serotonin receptor pulmonary arterial smooth muscle cell proliferation contraction |
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