| 阿托伐他汀对蛛网膜下腔出血后脑血管痉挛的干预作用 |
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| 引用本文： | 唐霍全,仝海波,光俊荣,范益民,刘跃亭,郝解贺. 阿托伐他汀对蛛网膜下腔出血后脑血管痉挛的干预作用[J]. 中西医结合心脑血管病杂志, 2010, 8(4): 463-464 |
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| 作者姓名： | 唐霍全 仝海波 光俊荣 范益民 刘跃亭 郝解贺 |
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| 作者单位： | 1. 山西医科大学,030001
2. 山西医科大学第一临床医学院 |
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| 摘 要： | 目的 探讨应用阿托伐他汀对蛛网膜下腔出血(SAA)后脑血管痉挛(CVS)的干预作用.方法 取健康SD雄性大鼠30只,随机将大鼠分为假手术组、SAH组、阿托伐他汀组,每组10只大鼠.以上各组分别于第1次手术后7 d灌注处死,取基底动脉行HE染色,测量其内径周长和管壁厚度;TUNEL法检测BA平滑肌细胞的凋亡率.结果假手术组、SAH组和阿托伐他汀组基底动脉的内径周长和管壁厚比较,三组之间两两比较均有统计学意义(P<0.05或P<0.01).各组基底动脉平滑肌细胞的凋亡率比较,三组之间两两比较均有统计学意义(P<0.05).结论 阿托伐他汀可以诱导基底动脉平滑肌细胞的凋亡,早期应用对SAH后引发的CVS有一定的缓解作用.
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| 关 键 词： | 蛛网膜下腔出血 脑血管痉挛 阿托伐他汀 大鼠 |
Effect of Atorvastatin on Cerebral Vasospasm after Subarachnoid Hemorrhage |
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| Tang Huoquan,Tong Haibo,Guang Junrong,et al. Effect of Atorvastatin on Cerebral Vasospasm after Subarachnoid Hemorrhage[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2010, 8(4): 463-464 |
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| Authors: | Tang Huoquan Tong Haibo Guang Junrong et al |
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| Affiliation: | Tang Huoquan,Tong Haibo,Guang Junrong,et alDepartment of Neurology , neurosurgery,The First Hospital,Shanxi Medical University (Taiyuan 030001) |
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| Abstract: | Objective To investigate the effect of atorvastatin on cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods Thirty healthy Sprague-Dawley male rats were randomly divided into three groups:Sham-operation group(n=10),SAH group (n=10) and atorvastatin group (n=10).All rats were sacrificed at 7th day after operation and got the basilar arteries(BA) for HE staining.The perimeter of inside diameter and the thickness of vessel wall were measured.The apoptosis rate of basilar artery vascular smooth mu... |
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| Keywords: | subarachnoid hemorrhage cerebral vasospasm atorvastatin rats |
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