Coumarin incorporated triazoles: a new class of anticonvulsants |
| |
| Authors: | Bhat Mashooq A Al-Omar Mohammed A |
| |
| Affiliation: | Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box. 2457, Riyadh 11451, Kingdom of Saudi Arabia. mashooqbhat@rediffmail.com |
| |
| Abstract: | A series of coumarin incorporated 1,2,4- triazole compounds (1-14) were evaluated for their possible anticonvulsant and neurotoxic properties, log P values, pharmacophoric mapping and three dimensional structure analysis. Compound (6) with para-fluoro substitution showed significant anticonvulsant activity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
