A novel <Emphasis Type="Italic">DSPP</Emphasis>mutation is associated with type II dentinogenesis Imperfecta in a chinese family |
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| Authors: | Xianqin Zhang Lanying Chen Jingyu Liu Zhen Zhao Erjun Qu Xiaotao Wang Wei Chang Chengqi Xu Qing K Wang Mugen Liu |
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| Institution: | (1) Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China;(2) Department of Bioengineering, Henan Urban Engineering College, 467001 Pingdingshan, China;(3) Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195 Cleveland, Ohio, USA |
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| Abstract: | Background Hereditary defects of tooth dentin are classified into two main groups: dentin dysplasia (DD) (types I and II) and dentinogenesis
imperfecta (DGI) (types I, II, and III). Type II DGI is one of the most common tooth defects with an autosomal dominant mode
of inheritance. One disease-causing gene, the dentin sialophosphoprotein (DSPP) gene, has been reported for type II DGI. |
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