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Lack of preferential Vβ usage in synovial T cells of rheumatoid arthritis patients |
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| Authors: | Fatma Dedeoglu Hulya Kaymaz Norma Seaver Samuel F. Schluter David E. Yocurn John J. Marchalonis |
| Affiliation: | 1. Department of Microbiology, Istanbul School of Medicine, Istanbul, Turkey 2. Department of Microbiology and Immunology, University of Arizona, AZ85724, Tucson, Ariz., (USA) 3. Department of Medicine, Section of Rheumatology, College of Medicine, University of Arizona, Tucson, Ariz., USA |
| Abstract: | The T-cell receptor Vβ subfamily repertoires of synovial and peripheral T cells of 8 rheumatoid arthritis (RA) patients were determined using the polymerase chain reaction. Three normal controls were included. Some of the rheumatoid synovial samples did not express the complete range of Vβ families and lacked as many as 6 gene families. However, these patients showed considerable individual variation in expression. Overall, the data do not support preferential T-cell receptor Vβ usage in synovial T cells of RA patients either in comparison to their autochthonous peripheral T cells or to peripheral T cells of normal subjects. |
| Keywords: | T-cell receptors Autoimmunity Polymerase chain reaction |
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