Quantitative-trait-locus Mapping in the Presence of Locus Heterogeneity |
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| Authors: | K Wang Y Peng |
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| Affiliation: | Program in Public Health Genetics College of Public Health The University of Iowa Iowa City, Iowa USA;Department of Mathematics and Statistics Memorial University of Newfoundland St. John's, Newfoundland A1C 5S7 Canada |
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| Abstract: | Locus heterogeneity is a concern for quantitative trait locus mapping where phenotypes are likely to be influenced by more than one gene. We introduce a model which generalizes the locus heterogeneity model of Smith (1961) from dichotomous traits to quantitative traits and consider some test statistics for this model. The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes. |
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| Keywords: | linkage analysis QTL locus heterogeneity score statistic |
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