| 可逆性胆碱酯酶抑制剂二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯的合成 |
| |
| 引用本文： | 王林,董永明. 可逆性胆碱酯酶抑制剂二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯的合成[J]. 药学学报, 1988, 23(3): 213-217 |
| |
| 作者姓名： | 王林 董永明 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所 北京(王林)，军事医学科学院毒物药物研究所 北京(董永明) |
| |
| 摘 要： | 在催醒安的邻位和对位异构体及其同系物的苯坏上引入烷基后,可以增强抑制胆碱酯酶的活性,我们乃进一步在催醒安及其同系物的苯环不同位置上引入叔丁基,合成了一系列二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯(Ⅰ_(1～13)和Ⅱ_(1～5))(表2),以探索对活性的影响。
|
| 关 键 词： | 胆碱酯酶抑制剂 二甲氨基甲酸-[3-(烷氨基)烷氧基-4-叔丁基]苯酯 二甲氨基甲酸-[3-(烷氨基)烷氧基-5-叔丁基]苯酯 |
| 收稿时间： | 1987-04-15 |
SYNTHESIS OF 3-(ALKYLAMINO) ALKOXY-4(5)-t-BUTYLPHENYL N, N-DIMETHYLCARBAMATES AS REVERSIBLE CHOLINESTERASE INHIBITORS |
| |
| L Wang and YM Dong. SYNTHESIS OF 3-(ALKYLAMINO) ALKOXY-4(5)-t-BUTYLPHENYL N, N-DIMETHYLCARBAMATES AS REVERSIBLE CHOLINESTERASE INHIBITORS[J]. Acta pharmaceutica Sinica, 1988, 23(3): 213-217 |
| |
| Authors: | L Wang and YM Dong |
| |
| Abstract: | A series of 3-(dialkylamino) alkoxy-4 (5)-t-butylphenyl N, N-dimethylcarbamates(Ⅰ and Ⅱ), which are the nuclear alkylated derivatives of 3-(2-dimethylamino) ethoxyphenyl N, N-dimethylcarbamate (CUI XING AN) was prepared as potential anticholinesterase agents. Preliminary screening tests showed that the introduction of t-butyl group in CUI XING AN and its homologs decreased the toxicity and anticholinesterase activity. Compounds of type Ⅰ have increased protective activity against organophosphorus poisoning. |
| |
| Keywords: | Cholinesterase inhibitor 3-(Alkylamino)alkoxy-4-t-butylphenyl N N-dimethylcarbamates 3-(Alkylamino)alkoxy-5-t-butylphenyl N N-dimethylcarbamates |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
