An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma |
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Authors: | Goshi Nishimura Shunsuke Yanoma Kenichi Satake Yoichi Ikeda Takahide Taguchi Yoshiyasu Nakamura Fumikazu Hirose Mamoru Tsukuda |
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Institution: | Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004;Research Institute, Kanagawa Cancer Center, 1–1–2 Nakao, Asahi-ku, Yokohama 241–0815 |
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Abstract: | An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)-2 inhibitor, probucol, an antioxidant, and S-1, an oral pro-drug of 5-fluorouracil (5-FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5-FU when coadministered with S-1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma. |
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Keywords: | COX-2 inhibitor Antioxidant S-1 Tumor dormancy Head and neck carcinoma |
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