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An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
Authors:Goshi Nishimura  Shunsuke Yanoma  Kenichi Satake  Yoichi Ikeda  Takahide Taguchi  Yoshiyasu Nakamura  Fumikazu Hirose  Mamoru Tsukuda
Institution:Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004;Research Institute, Kanagawa Cancer Center, 1–1–2 Nakao, Asahi-ku, Yokohama 241–0815
Abstract:An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)-2 inhibitor, probucol, an antioxidant, and S-1, an oral pro-drug of 5-fluorouracil (5-FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5-FU when coadministered with S-1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma.
Keywords:COX-2 inhibitor  Antioxidant  S-1  Tumor dormancy  Head and neck carcinoma
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