Isometric skeletal muscle force measurement in primary myopathies |
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| Authors: | Hans F. Ginz MD Paul A. Iaizzo PhD Kathi Schweikert MD William K. Durfee PhD |
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| Affiliation: | 1. Department of Anesthesia and Biomedicine, University Hospital, Basel, Switzerland;2. Department of Surgery, Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA;3. FMH Neurology, REHAB Basel AG, Basel, Switzerland;4. Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA |
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| Abstract: | Introduction: In myopathy patients, it is useful to measure skeletal muscle forces. Conventional methods require voluntary muscle activation, which can be unreliable. We evaluated a device for nonvoluntary force assessment. Methods: We tested 8 patients (unknown myopathy n = 2, inflammatory myopathy, facioscapulohumeral muscular dystrophy, mitochondrial myopathy, dysferlinopathy, multi‐minicore disease, Becker‐Kiener muscular dystrophy, n = 1 each). Isometric twitch torques of ankle dorsiflexors were measured after fibular nerve stimulation. Results: Six patients had decreased torques vs. 8 controls (men: median Newton‐meter 1.6 vs. 5.7, women: 0.2 vs. 3.9, both P < 0.0001). Values correlated with Manual Muscle Test results (r = 0.73; r2 = 0.53; P < 0.0001). In weak dorsiflexors, torque could be measured despite lower signal‐to‐noise ratios. In 2 patients with hypertrophy, we measured increased torques. Conclusions: Nonvoluntary muscle force assessment can be used in patients with myopathies, and values correlate with voluntary forces determined by traditional methods. Muscle Nerve 53 : 913–917, 2016 |
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| Keywords: | isometric contraction distal myopathy muscle skeletal strength |
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