Validation of the besta neurological institute rating scale for myasthenia gravis |
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| Authors: | Carlo Antozzi MD Greta Brenna MSc Fulvio Baggi PhD Giorgia Camera MD Lorenzo Maggi MD Cristiana Rezzani PhD Cristina Montomoli PhD Renato Mantegazza MD |
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| Affiliation: | 1. U.O. Neurologia IV ‐ Neuroimmunologia e Malattie Neuromuscolari, Fondazione IRCCS Istituto Nazionale Neurologico C. Besta, Milano;2. Unità di Biostatistica ed Epidemiologia Clinica, Dipartimento Sanità Pubblica, Medicina Sperimentale e Forense, Università di Pavia, Pavia, Italy |
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| Abstract: | Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB‐MG scale). Methods: A total of 174 patients were evaluated with the INCB‐MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB‐MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB‐MG subscales were unidimensional with excellent consistency; the INCB‐MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB‐MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB‐MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB‐MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials. Muscle Nerve 53 : 32–37, 2016 |
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| Keywords: | disability Myasthenia Gravis outcome rating scale validation |
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