雷米普利治疗慢性充血性心衰的临床观察

目的:比较雷米普利、地高辛、利尿剂合用与地高辛、利尿剂合用对慢性充血性心力衰竭(CHF)患者心功能、左室射血分数(LVEF)、左室舒张末期内径(LVED)的影响。方法:110例CHF患者随机分为两组,分别接受雷米普利、地高辛、利尿剂(雷米普利组)及地高辛加利尿剂(对照组),治疗3个月。结果:雷米普利组心功能明显改善,LVED由(6 8.2±4.3)mm减少到(60.1±3.3)mm,LVEF由34.7%±8.9%增加到43.4%±9%,治疗前后比较,P均<0.01,对照组心功能明显改善,但LVED、LVEF无明显变化。结论:雷米普利组治疗CHF患者,对降低LVED、提高LVEF疗效较好。

Clinical observation of ramipril on treatment of chronic consgestive heart failure

Object: To compare the effects of ramipril,digoxin and Diuretic with digoxin and diuretic on cardiac function,left ventricular ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVED) in chronic congestive heart failure(CHF) patients.Methods:110 patients were divided randomized into two groups.One group(experimental group) received ramipril,digoxin and Diuretic,the other group(control group) received digoxin and diuretic.Treatments were all lasted for 3 months.Results: Both of groups had significant improvement on cardiac function.But the LVED were reduced and LVEF were increased significantly in experimental group.No changes were observed in control group.There were significant differences between two groups for LVED and LVEF.Conclusion: The treatment with ramipril,digoxin and Diuretic was more effective than that with digoxin and diuretic on LVEF and LEVED in CHF patients.