超氧化物歧化酶在膝骨关节炎患者血清中的变化及相关因素分析

目的研究膝骨关节炎(KOA)患者血清超氧化物歧化酶(SOD)的变化及其影响因素。方法比色法测定62例KOA患者血清SOD,并与年龄、症状积分、性别、病程、膝关节功能影响指数(Lequesne MG)及红细胞沉降率(ESR)、超敏C反蛋白(CRP)等实验室指标进行相关性分析。结果 62例KOA患者血清SOD值与正常参考值比较,下降的有36例,下降异常率达58%;轻、中、重度组血清SOD比较,重度组低于中度组,中度组低于轻度组(P<0.05);相关性分析显示,SOD与病程、Lequesne MG、中医症候积分、ESR、CRP、免疫球蛋白M(IGM)呈负相关,与C3、C4呈正相关(P<0.05),而与年龄、性别、白细胞(WBC)、红细胞(RBC)、血红蛋白(HGB)、血小板(PLT)、免疫球蛋白G(IGG)、免疫球蛋白A(IGA)无相关性(P>0.05)。结论 KOA患者血清SOD显著降低,其表达失调参与了KOA发病。

The change and correlation analysis of serum superoxide dismutase in patients with knee osteoarthritis

Objective To observe the change of serum superoxide dismutase （SOD） in the knee osteoarthri- tis （KOA） patients and explore the influence of the related factors. Methods The serum levels of SOD in 62 KOA patients were detected using colorimetric method, and the data of age, symptom score, sex, course, the severity of knee osteoarthritis index （Lequesne MG）,blood sedimentation （ESR） and allergic C protein （CRP） were collected and the correlation with SOD level was analyzed. Results There were 36 cases with serum level of SOD below the refer- ence value,i, e. the abnormal rate was 58% in the patients with knee osteoarthritis. According to the severity of knee osteoarthritis index （Lequesne MG） ,62 KOA patients were divided into 3 groups,i, e. mild group, moderate group and severe group. The SOD level in the moderate group was lower than that in mild group. Similarly, the SOD level in the severe group was lower than that in the moderate group （ P 〈 0.05 ）. Serum SOD level was negatively related to the course, Lequesne MG, integral of TCM symptoms, ESR, CRP and immunoglobulin M （ IGM ）, and positively related to C3 and CA （ P 〈 0.05 ）, but has no correlation to age, gender, white blood cells （ WBC ）, red blood cells （ RBC ）, hemoglobin （HGB）, platelet （PLT）, immunoglobulin G （IGG） or immune globulin A （IGA）. Conclusion Serum SOD level is obviously decreased in patients with KOA, the abnormal expression of SOD is involved in the pathological progress of KOA.