家庭氧疗及双水平无创通气对重叠综合征患者血气分析结果和生活质量的影响

目的探讨家庭氧疗及双水平无创通气对重叠综合征患者血气分析结果和生活质量的影响。方法 38例经家庭氧疗和42例经双水平无创通气治疗的重叠综合征患者,分析治疗前后患者血液中pH、PaO2,PaCO2值变化情况,并通过调查问卷方式分析治疗前后生活质量。结果双水平无创通气组治疗后血pH和血PaO2均显著高于治疗前(均P<0.05),血PaCO2显著低于治疗前(P<0.05);家庭氧疗组治疗前后血pH、PaO2和血PaCO2均差异无统计学意义(均P>0.05)。双水平无创通气组血pH值和PaO2随治疗时间加长均逐渐升高(均P<0.05),血PaCO2随治疗时间加长逐渐下降趋于正常值(均P<0.05);但家庭氧疗组血pH、PO2和血PaCO2随治疗时间变化差异无统计学意义(均P>0.05)。双水平无创通气组患者生活质量均显著升高,家庭氧疗组患者生活质量无明显改变。结论双水平无创通气治疗对重叠综合征患者血气分析结果和生活质量的影响大于家庭氧疗,可大量应用于重叠综合征。

The effect of home oxygen therapy and non-invasive bi-level positive pressure ventilation on blood gas changes and the life quality in patients with overlap syndrome

Objective To investigate the effect of home oxygen therapy and non-invasive bi-level positive ventilation （BiPAP） on blood gas changes and life quality of patients with overlap syndrome. Methods 38 patients with home oxygen therapy treatment and 42 patients with BiPAP treatment were selected, and blood gas analysis（pH, PaO2 ,and PaCO2 values） and questionnaire of life quality were used to analyze the home oxygen therapy and non-in- vasive bi-level positive ventilation （BiPAP） on blood gas changes and life quality. Results Blood pH and PaO2 of BiPAP group after treatment were significantly higher than those before treatment （P 〈 0.05）. Blood PaCO2 of BiPAP group after treatment were significantly lower than those before treatment （ P 〈0. 05 ）. There was no significant difference between blood PH, PO2 and blood PaCO2 of home oxygen therapy group before and after treatment. Blood pH and PaO2 BiPAP group increased with time during the treatment period （ P 〈 0.05 ）, and blood PaCO2 of BiPAP group de- creased gradually the normal level（P 〈0.05） ,there was no significant difference between blood pH, PaO2 and blood PaCO2 of home oxygen therapy group during the treatment period. Life quality of the patients of BiPAP group significantly was improved, but not in the home oxygen therapy group. Conclusion The non-invasive bi-level positive pressure ventilation （BiPAP） can improve effect blood gas changes and life quality of patients with overlap syndrome more significant than the home oxygen therapy.