| 大环多内酯类抗生素FKI-0076E2的分离及结构鉴别 |
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| 引用本文： | 孙承航,荒井雅吉,供田洋,大村智. 大环多内酯类抗生素FKI-0076E2的分离及结构鉴别[J]. 中国抗生素杂志, 2002, 27(2): 80-83 |
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| 作者姓名： | 孙承航 荒井雅吉 供田洋 大村智 |
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| 作者单位： | 1. 中国医学科学院,中国协和医科大学,医药生物技术研究所,北京,100050
2. 日本北里研究所,日本国东京都港区白金5-9-1 |
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| 摘 要： | 在以微生物次级代谢产物为来源的 ,唑类抗真菌药物活性增强剂的筛选过程中 ,从一株真菌Talaromyces sp FKI- 0 0 76的发酵液中 ,经反向 ODS柱层析和反向半制备高效液相色谱的分离 ,获得一个分子量为 6 6 2的不稳定大环多内酯类抗生素 :FKI- 0 0 76 E2。光谱分析表明 ,它与 BK2 2 3- B同质。根据对 FKI-0 0 76 E2不稳定性的研究 ,首次提出了化学结构变化可能的机理
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| 关 键 词： | FKI-0076E2 BK223-B 增强剂 唑类 大环多内酯 结构互变 |
| 文章编号： | 1001-8689(2002)02-0080-04 |
Isolation, structural identification of FKI-0076E2, an unstable macrocyclic polylactones from Talaromyces sp. FKI-0076 |
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| Sun Cheng hang ,Alai M ,Tomoda H ,Omura S. Isolation, structural identification of FKI-0076E2, an unstable macrocyclic polylactones from Talaromyces sp. FKI-0076[J]. Chinese Journal of Antibiotics, 2002, 27(2): 80-83 |
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| Authors: | Sun Cheng hang Alai M Tomoda H Omura S |
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| Affiliation: | Sun Cheng hang 1,Alai M 2,Tomoda H 2,Omura S 2 |
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| Abstract: | In the course of screening for substances indicating synergistic effects with clinic used miconazole as well as antifungal agent, a unstable macrocyclic polylactones: FKI 0076E2 was extracted and isolated from fermentation broth of a fungi: Talaromyces sp. FKI 0076 by ODS open column and semi preparative HPLC. Based on spectroscopic data and the comparison with those of BK223 B, FKI 0076E2 was structurally identified as BK223 B. For the first time, the chemical mechanism of mutual transformation of FKI 0076E2, FKI 0076E1 and FKI 0076A was proposed; Opening of cyclic lactone of the macrocyclic polylactones in water causes the unstability. |
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| Keywords: | FKI 0076E2 BK223 B Synergist Azole Macrocyclic polylactones Mutual transformation |
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