Free-radical oxidation during experimental pneumonia |
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| Authors: | U R Farkhutdinov R R Farkhutdinov |
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| Institution: | (1) Interinstitute Laboratory of Technical Systems for Medico-Biological Investigations, Bashkir State Medical University, Ufa;(2) Interinstitute Laboratory of Technical Systems for Medico-Biological Investigations, Aviation Technical University, Ufa |
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| Abstract: | Lipid peroxidation in the lungs and plasma of albino rats was studied under normal conditions and during experimental pneumonia.
In intact rats the content of lipid peroxidation products and the rate of their accumulation in lung homogenate is lower than
in homogenates of other organs. Bivalent iron ions added to blood plasma did not induce chemiluminescence characteristic of
lipid peroxidation. Experimental pneumonia intensifies production of active oxygen forms by alveolar macrophages and blood
neutrophils and increases the content of lipid peroxidation products in lung homogenate. Combined application of antibiotics
and antioxidant (vitamin E) during experimental pneumonia promotes normalization of free-radical oxidation and diminishes
morphological alterations in the lungs.
Translated fromByulleten' Eksperimental'noi Biologii i Medistiny, Vol. 129, No. 3, pp. 260–264, March, 2000 |
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| Keywords: | pneumonia lipid peroxidation chemiluminescence |
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