Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos. |
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| Authors: | M Nehéz G W Fischer H Scheufler R Schmidt T Sipos I Dési |
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| Institution: | Department of Hygiene and Epidemiology, Albert Szent-Gy?rgyi University Medical School, Szeged, Hungary. |
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| Abstract: | The organophosphorus herbicide buminafos (O,O-dibutyl-(1-butylaminocyclohexyl)-phosphonate) was tested for its acute toxic, cytogenetic, and embryotoxic activity on different strains of mice. The oral LD50 value for male NMRI mice was determined to be 3500 mg/kg. Single oral doses of 175, 1000, and 2000 mg/kg did not cause any significant enhancement in the percentage of chromosome aberrations in bone marrow cells of male NMRI mice. After oral administration of 500 and 1000 mg/kg buminafos to pregnant Halle:DBA and Halle:AB mice at Days 6-15 of gestation no embryotoxic effects were observed. The cytogenetic inactivity of buminafos in the bone marrow chromosome assay corresponds to negative findings in other mutagenicity tests. |
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