| X-box-binding protein 1-modified neural stem cells for treatment of Parkinson’s disease |
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| 摘 要： | X-box-binding protein 1-transfected neural stem cells were transplanted into the right lateral ventricles of rats with rotenone-induced Parkinson’s disease. The survival capacities and differentiation rates of cells expressing the dopaminergic marker tyrosine hydroxylase were higher in X-box-binding protein 1-transfected neural stem cells compared to non-transfected cells. Moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of X-box-binding protein 1-transfected neural stem cells. These results indicate that transplantation of X-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of Parkinson’s disease in rats.
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| 关 键 词： | X-box-binding protein 1 neural stem cells Parkinson’s disease α-synuclein dopamine |
| 收稿时间： | 2012 Jan 6 |
X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease |
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| Authors: | Lihui Si Tianmin Xu Fengzhang Wang Qun Liu Manhua Cui |
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| Institution: | 1Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China 2Department of Neurology, Norman Bethune First Hospital of Jilin University, Changchun 130021, Jilin Province, China |
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| Abstract: | X-box-binding protein 1-transfected neural stem cells were transplanted into the right lateral ventricles of rats with rotenone-induced Parkinson’s disease. The survival capacities and differentiation rates of cells expressing the dopaminergic marker tyrosine hydroxylase were higher in X-box-binding protein 1-transfected neural stem cells compared to non-transfected cells. Moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of X-box-binding protein 1-transfected neural stem cells. These results indicate that transplantation of X-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of Parkinson’s disease in rats. |
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| Keywords: | X-box-binding protein 1 neural stem cells Parkinson’s disease α-synuclein dopamine |
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