吡格列酮与二甲双胍联合治疗2型糖尿病抵抗的对照研究

目的 探讨观察吡格列酮与二甲双胍联合治疗2型糖尿病(T2DM)的临床疗效.方法 选择2010年6月-2011年11月在我院诊治的150例2型糖尿病患者,将其随机分为治疗组50例,其中男性30例,女性20例,平均年龄(44±6.4)岁,给予吡格列酮15 mg,每日1次,二甲双胍0.5 g,每日2次.治疗6个月以上;对照A组50例,男性28例,女性22例,平均年龄(43±7.5)岁.单用吡格列酮15 mg,每日1次;对照B组50例,男性30例,女性20例,平均年龄(45±7.8)岁,单用二甲双胍治疗0.5 g,每日2次.均治疗6个月以上.观察治疗前后空腹血糖(FPG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、餐后2 h胰岛素(P2hlNS)水平等各项指标的变化.结果 治疗后,治疗组的各项检查指标较单用吡格列酮组和单用二甲双胍组较治疗前明显好转(P<0.01).结论 吡格列酮联合二甲双胍治疗2型糖尿病有良好的临床疗效.

Effects of pioglitazone and metformin in treating type 2 diabetes mellitus resistance control study

Objective To investigate the observation of pioglitazone and metformin in type 2 diabetes(T2DM) clinical efficacy.Methods June 2010 in our hospital in Novenber 2011,150 cases of type 2 diabetes,were randomly divided into treatment group 50 cases,including 30 males,20 females,mean age(44±6.4) years,given pioglitazone 15 mg,day 1,metformin 0.5 g,2 times a day.Treatment for more than 6 months;control group A 50 cases,28 males and 22 females,average age(43±7.5) years.15 mg of rosiglitazone with pioglitazone alone once a day;control group B 50 cases,30 males,20 females,mean age(45±7.8) years old,single with metformin 0.5 g,2 times a day.Were treated for 6 months or more.Before and after treatment fasting plasma glucose(FPG),postprandial 2 h blood sugar(P2hBG),glycated hemoglobin(HbAlc),fasting insulin(FINS),postprandial 2 h insulin(P2hlNS) the level of the index changes.Results After treatment,the check indicator of the treatment group compared with single-use combination of pioglitazone alone significant improvement in the metformin group than in the pre-treatment(P <0.01).Conclusion Pioglitazone and Metformin treatment of type 2 diabetes have good clinical efficacy.