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Mucinous tubular and spindle cell carcinoma with aggressive histomorphology--a sarcomatoid variant |
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| Authors: | Pillay Nischalan Ramdial Pratistadevi K Cooper Kumarasen Batuule David |
| Affiliation: | a NHLS, Inkosi Albert Luthuli Central Hospital, Durban, South Africa b Department of Anatomical Pathology, NHLS, Inkosi Albert Luthuli Central Hospital, Durban, South Africa c Vice Chair Anatomical Pathology, University of Vermont, Burlington, VT, USA d St. Aidens Mission Hospital, Durban, South Africa |
| Abstract: | Mucinous tubular and spindle cell carcinoma (MTSCC) is a recently described renal epithelial tumor. The bland cytomorphology of the spindled component and low-grade behavior help in its differentiation from sarcomatoid renal carcinoma. Sarcomatoid change has been reported in most histologic variants of renal cell carcinoma apart from MTSCC. Herein we report a case of an MTSCC in a 72-year-old female patient with high-grade spindled areas resembling fibrosarcomatous and undifferentiated pleomorphic sarcoma patterns with metaplastic bone. This index case also demonstrates a high proliferation index and extensive necrosis representing the first documented case of sarcomatoid change in MTSCC. |
| Keywords: | Mucinous tubular and spindle cell carcinoma Sarcomatoid carcinoma |
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