实验性动脉再狭窄动物模型的构建与研究

目的：建立再狭窄动物实验模型。方法：采用右髂动脉球囊内皮剥落术加高胆固醇喂饲家兔。结果：经血管造影检查，右髂动脉平均狭窄程度血管成形术前在60％以上，术后5周在50%；病理切片和组织生化显示内膜明显增厚，可见大量泡沫细胞，脂质沉积显著增加；透射电镜和免疫组织化学鉴定显示，增生内膜主要是平滑肌细胞增殖。结论：采用本方法可以成功地建立再狭窄动物模型，增生的内膜主要是平滑肌细胞增殖。

Setting up experimental animal model of restenosis

Objective:Setting up the experimental animal model of restenosis.Method:To use the endothlium peeling technique through the right iliac artery and to feed the rabbits with high cholesterol.Results:Inspect by angiography,the stenosis degree of the right iliac artery is over 60% febore the angioplasty.The steosis degree of the right iliac artery is over 50% after angioplasty.Pathological and histological results show that thickness of endothelium is increased and large quantities of the foaming cell can be seen,lipid deposit increased obviously;electro-microscope and immuno-histo-chemistry results show the increased endothelium is smoth muscle cell(SMC).Conclusion:Experimental animal model of re-stenosis can be set up by this technique and the proliferated cell mainly is SMC.