Lumican基因在大肠癌中的表达及其预后的关系

目的 研究Lumican基因在大肠癌及癌旁正常组织中的表达,并探讨其与大肠癌生物学行为及预后的关系.方法 应用免疫组织化学方法,检测205例大肠癌原发灶及50例癌旁正常组织中lumican基因表达情况,观察其表达与大肠癌生物学行为及预后的关系.结果 Lumican在大肠癌组织中阳性表达率为75.61%(155/205);而在大肠癌旁正常组织中Lumican表达阳性率仅为12.0%(6/50),且均为弱阳性表达.Lumican表达水平与肿瘤浸润深度和病理分型密切相关(x2=16.201,P=0.013;x2=9.506,P=0.029),而与肿瘤分期和淋巴结转移无关(x2=15.457,P=0.079;x2=1.887,P=0.596).Lumican表达阴性组、弱阳性组、阳性组和强阳性组患者平均生存时间分别为64.9月、56.6月、41.5月和36.4月,组间差别有统计学意义(x2=35.066,P=0.000).结论 Lumican表达水平与大肠癌侵袭能力密切相关,并可作为判断大肠癌患者预后的重要指标之一.

Lumican expression and its relationship with biological behavior and prognosis in colorectal cancer

Objective To investigate the expression of Lumican in human colorectal cancer tissues and normal colorectal tissues, and its relationship with biological behavior and survival rate. Methods By using immunohistochemistry, we studied the Lumican expression patterns in 205 cases of colorectal cancers with rarious clinico-pathologic characteristics, and 50 normal colorectal tissues specimens. The relationship of Lumican expression with the biological behavior and survival of patients was evaluated. Results The expression rate of Lumican in normal colorectal tissues was 12.0%(6/50), and their expression was weaker expression. In sharp contrast, Lumican expression rate in colorectal cancer lesions was 75.61%(155/205). Lumican protein expression was closely related to the location of tumor, the depth of tumor invasion and histological types(x2 =16. 201, P = 0. 013;x2 = 9. 506, P = 0. 029), but not related to the number of metastatic lymph nodes and stage (x2 = 15. 457, P = 0. 079;x2 = 1. 887,P = 0. 596). The medium survival time in patients who had a tumor with negative, weak, postive and strong Lumican expression was 64.9、56.6、41.5 and 36.4 months, respectively (x2 =35. 066,P =0.000). Conclusion Normal and malignant colorectal tissues have unique Lumican expression patterns.Lumican might be served as an independent prognostic marker.