| 复方地塞米松搽剂的制备及质量控制 |
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| 引用本文： | 刘广军,吴慧英,翁春梅,刘旻虹,丁建.复方地塞米松搽剂的制备及质量控制[J].中国药房,2005,16(20):1551-1552. |
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| 作者姓名： | 刘广军 吴慧英 翁春梅 刘旻虹 丁建 |
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| 作者单位： | 1. 江苏常州市第二人民医院,常州市,213003
2. 江苏常州市药品检验所,常州市,213003 |
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| 摘 要： | 目的:制备复方地塞米松搽剂并建立其质量控制方法。方法:以氮酮为促透剂、乙醇为溶剂制备复方地塞米松搽剂,采用高效液相色谱法测定制剂中主药醋酸地塞米松和维生素E的含量。结果:醋酸地塞米松、维生素E检测浓度分别在2~40μg/ml、80~800μg/ml范围内呈良好线性关系,平均回收率分别为100·5%(RSD=0·82%)、98·6%(RSD=0·59%)。结论:该制剂处方合理,质量控制方法简便、准确。
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| 关 键 词： | 复方地塞米松搽剂 制备 质量控制 高效液相色谱法 |
| 文章编号： | 1001-0408（2005）20-1551-02 |
| 收稿时间： | 2005-04-27 |
| 修稿时间： | 2005-06-06 |
Preparation and Quality Control of Compound Dexamethasone Liniment |
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| LIU Guangjun,WU Huiying,WENG Chunmei,LIU Minghong,DING Jian.Preparation and Quality Control of Compound Dexamethasone Liniment[J].China Pharmacy,2005,16(20):1551-1552. |
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| Authors: | LIU Guangjun WU Huiying WENG Chunmei LIU Minghong DING Jian |
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| Abstract: | OBJECTIVE:To establish a method for preparation and quality control of compound dexamethasone liniment.METHODS:The compound dexamethasone liniment were prepared with dexamethasone acetate and vitamin E,the contents were determined by HPLC.RESULTS:The calibration curves of dexamethasone acetate and vitamin E were linear in the range of2～40μg/ml and80～800μg/ml respectively,and their average recoveries were100.5%(RSD=0.82%)and98.6%(RSD=0.59%)respectively.CONCLUSION:The preparation is reasonable in formula,simple and accurate in quality control. |
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| Keywords: | Compound dexamethasone liniment Preparation Quality control HPLC |
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