T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值

目的 探索结核感染T细胞斑点试验(T-SPOT.TB)检测用于脂膜炎患者中结核感染病因分析的价值.方法 回顾性分析2011-2013年我院159例病理诊断为脂膜炎并进行T-SPOT.TB检测的患者的临床及组织病理资料,并对其中的92名患者进行3年的随访,31名健康人作研究对照.结果 脂膜炎中T-SPOT.TB检查阳性率为76.1％,显著高于正常人群(9.7％,P＜0.001);抗结核治疗患者有效率为75.3％,复发率为20.0％,其中完成6个月疗程的患者复发率显著低于3个月内停药的患者(P＜0.05).结论 T-SPOT.TB检测对于查找结核感染相关的脂膜炎患者有一定的价值.

Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients

Objective To explore the significance of T-SPOT.TB assay in the etiological analysis for panniculitis patients.Methods We retrospectively reviewed the clinical and histopathological features of 159 cases of panniculitis diagnosed in our hospital who underwent T-SPOT.TB assay from January 2011 to December 2013.And 92 cases of them were followed up by telephone for 3 years.Another 31 health individuals served as normal control.Results The overall positive rate to T-SPOT.TB assay was 76.1％ in the panniculitis patients,significantly higher than that of healthy subjects (9.7％,P ＜ 0.001).The overall effective rate was 75.3％ for anti-tuberculosis treatment,and the recurrence rate was 20.0％.The patients who accomplished treatment course of 6 months had obviously lower recurrent rate than those who only have in 3 months' treatment (P ＜ 0.05).Conclusion T-SPOT.TB assay is valuable to detect the tuberculosis infection in panniculitis patients.