Effect of spironolactone on hypertrophy of left ventricular myocardium in Wistar rats with experimental uremia |
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| Authors: | A. Zh. Karabayeva A. M. Esaian I. G. Kayukov M. M. Parastaeva O. N. Beresneva L. V. Kotenko I. E. Sevastyanova |
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| Affiliation: | (1) Department of Nephrology and Dialysis, Faculty of Postgraduate Education, St. Petersburg, Russia;(2) Department of Clinical and Laboratory Diagnostics, I. P. Pavlov State Medical University, St. Petersburg, Russia |
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| Abstract: | Chronic renal failure was modeled in rats by partial nephrectomy. Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated. In rats treated with spironolactone, the index of myocardial hypertrophy did not considerably differ from that in sham-operated animals, whereas in untreated rats the test parameters considerably differ from the control. We concluded that the blockade of aldosterone receptors with spironolactone produced a cardioprotective effect in Wistar rats with subtotal nephrectomy. __________ Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 145, No. 6, pp. 659–662, June, 2008 |
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| Keywords: | aldosterone spironolactone arterial hypertension left-ventricular hypertrophy |
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